Green synthesis and antibacterial/fungal studies of two new Schiff base derived from 4-(imidazol-1-yl)benzaldehyde

Abstract

This study synthesizes two new Schiff bases, (E)-1-(4-1H-imidazol-1-yl)phenyl)-N-(o-tolyl)methanimine and (E)-1-(4-(1H-imidazol-1-yl)phenyl)-N-(m-tolyl)methanimine through condensation reaction between 4-(imidazol-1-yl)benzaldehyde and 2-toluidine/o-toluidine, respectively. FT-IR, X-ray diffraction and ¹H NMR spectroscopy have been carried out to characterize the structure of the products. Through antibacterial/ antifungal activity tests performed using 8 kinds of bacteria/fungus, it is found that the both of the two Schiff bases can suppress the growth of Staphylococcus, Bacillus subtilis and Salmonella, showing good potential as antibacterial drug.