Synthesis, characterization, drug likeliness and biological activity of imidazopyridine derivatives as anti-tubercular agents

Abstract

Tuberculosis is a global threat that is in urgent need for new molecules. In the same perspective, Imidazopyridine derivatives have been synthesized against target ATP synthase. It is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most organisms. Bedaquiline that primarily targets ATP now is most effective in treatment of tuberculosis. All synthesized molecules pass Lipinski rule of 5 and are non-substrate of CYP450 enzymes. They didn’t portray significant anti-tubercular activity.