Triton-B/CS2 mediated novel synthesis of substituted thioureas: A novel class of anti-cancer agents

Abstract

A novel method for the synthesis of substituted thioureas is being reported in this communication making use of easily available, less toxic and cost effective chemicals at normal conditions of temperature and pressure. The reaction of various aliphatic and aromatic amines with CS₂, methyl iodide using Triton-B as phase transfer catalyst led to the formation of substituted thioureas. This new method involved one flask reaction at room temperature and pressure conditions with high yield and easier separation of compound from the reaction mixture.