Characterization of the 2-hydroxy-5-methylacetophenone and some aromatıc aldehydes condensation products by NMR and computational methods

Abstract

A two-component Claisen-Schmidt condensation between the 2-hydoxy-5-methylacetophenone and some aromatic aldehydes has been carried out for the synthesis of chalcone derivatives at ambient temperature. The products have been obtained with good yields and as a mixture of two compounds or a single product. Piperidine has been used as a catalyst for the in situ generation of carbanion from ketone. The possibility of the formation of different products has been investigated on the based PM7 optimization, HMO theory and NMR methods.