Synthesis and antitumor activity of novel N-(8-(3-ureidophenyl)imidazo [1,2-a]pyridin-6-yl)acetamide derivatives

Chen, Yu-Mei ; Chen, Dong-Mei ; Wu, Qing-Mei ; Ye, Wen-Jun ; Zhao, Chun-Shen ; Zhou, Zhi-Xu


A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been designed and synthesized and evaluated for antitumor activity against SMMC7721 cells and HCT116 cells in vitro in order to initially screen out their biological properties and to reveal the role of 8-substituted urea phenyl imidazo[1,2-a]pyridine fragment in the ability of compounds to antitumor activity. The antitumor activity test have shown that most compounds exhibit excellent anticancer activity against SMMC7721 cells and HCT116 cells. The experimental results have proved that N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acetamide derivatives containing imidazo[1,2-a]pyridine and urea are promising for further in-depth study of antitumor properties.


Imidazo[1,2-a]pyridine, Urea, Antitumor activity

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