Synthesis of some new isoxazole-piperidine-1,2,3-triazoles as in vitro anticancer agents

Abstract

The synthesis of some new isoxazole-piperidine-1,2,3-triazoles (4a-4j) have been achieved using Sharpless Cu(I) catalyzed [3+2] cycloaddition as a key approach. The in vitro anticancer screening of all the compounds against four human cancer cell lines including MCF-7, HeLa, A549 and IMR32 has revealed that the compounds 4c and 4f exhibited promising activity against all the cell lines as compared to etoposide. Rest of the compounds have shown good to zero activity against specific cell line when compared with the positive control. Predominantly, the compound 4c is showing superior activity against IMR32 which posses IC₅₀ value 3.2±0.3 mM.