Synthesis and evaluation of biological activity of some novel carbazole derivatives

Kumar, Umesh ; Gupta, Sujeet Kumar; Yogi, Bhumika ; Gautam, Surendra Kumar

Abstract

Natural and synthetic carbazoles contains potent activity against inflammation. Some novel carbazole derivatives have been synthesized and also checked for activity against inflammation by using Carrageenan Induced Inflammation in Rat Paw Edema Model. Structures of synthesized carbazole derivatives have been confirmed on the basis of FT-IR, 1H NMR and elemental analysis. During the evaluation of biological activity, newly synthesized compounds (4a) and (4f) are found more potent against inflammation.


Keyword(s)

Carbazole, Heterocyclic chemistry, Anti-inflammatory activity, Carrageenan induced Inflammation, Rat paw Edema model, Diclofenac sodium

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