A novel approach to determine anti-proliferative, anti-migratory and anti-microbial properties of 2-phenylethylammonium carboxylate molecular salts

Abstract

2-Phenylethylammonium (PEA) salt derivatives have been prepared between 2-phenylethylamine with various aromatic carboxylic acids (nicotinic, benzoic, salicylic, and γ-resorcylic) and confirmed by spectroscopic analyses. Additionally, the possible biological activities of these salts have been examined and the antiproliferative and antimigrative effects of salts on breast and colon cancer cell lines have been determined. Furthermore, to obtain preliminary data for the effects of the indicated compounds on cancer angiogenesis, in vitro migration analysis has been performed by human vascular endothelial cells. The antibacterial effects of the compounds have also been investigated. Therefore, an important contribution has been made to studies conducted to better recognize the pharmacological effects of salts.