Biological evaluation of some novel chalcones and their derivatives

Abstract

Chalcones, (E)-N-(4-(4,6-dichloro-1,3,5 –triazin-2-ylamino) phenyl)-3-(4 methoxy-phenyl) acrylamide 4a-c have been prepared by employing Claisen-Schmidt condensation. Further, these chalcones 4a-c on reaction with malononitrile afford cyano-pyridines 5a-c respectively. The constitution of newly synthesised compounds have been characterized on the basis of their IR, ¹H and ¹³C NMR spectral data. These synthesized compounds have been screened for their antibacterial and larvicidal activity.