An effective total synthesis of four angiotensin-converting enzymes containing silanediols

 

Duong, Hoan Quoc; Sieburth, Scott McN; Sieburth, Scott McN

Abstract

Four angiotensin-converting enzymes (ACE) containing silanediols 1 have been synthesized successfully in 8% overall yield in 8 steps from inexpensive starting materials such as diphenyldichlorosilane 5, b-methylallylic alcohol 7 and Ellman sulfinimine 9.



Keyword(s)

Angiotensin-converting enzymes, silandiol, Ellman sulfinimine, diphenyldichlorosilane, b-methylallylic alcohol, total synthesis


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