Effect of myricetin on cognitive impairments in the transgenic Drosophila model of Parkinson’s Disease

Ara, Gulshan ; Afzal, Mohammad ; Naz, Falaq ; I, Mantasha ; Shahid, M ; Siddique, Yasir Hasan

Abstract

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons. Despite the availability of many drugs to ease the life of PD patients, there is no permanent cure until now. Now-a-days, there has been a considerable attention towards the use of herbal products to treat PD patients worldwide due to less side effects. In this context, here we investigated myricetin, a common plant derived flavonoid, on the cognitive impairments exhibited by the transgenic Drosophila expressing human -synuclein in the neurons. The PD flies were allowed to feed on the diet having 10, 20 and 40 μM of myricetin for 24 days and then assayed for cognitive impairments. The exposure of myricetin showed a dose dependent significant delay in the cognitive impairments. Molecular docking studies showed the positive interaction between myricetin and -synuclein. The results suggest a protective effect of myricetin against the cognitive impairments.

Keyword(s)

Molecular docking; Neurodegenerative disorder; α-Synuclein

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