Hepatorenal protective action of Spirulina platensis against beryllium inducedhepatorenal dysfunction and histopathological alterations in rats

Raghuvanshi, Suchita ; Agrawal, Narottam Das; Rawat, Purneema ; Srivastava, Sadhana ; Shukla, Sangeeta

Abstract

Beryllium (Be) is highly toxic to human, induces oxidative stress and leads to Chronic Beryllium Disease (CBD) orberylliosis, apoptosis and cancer. In this study, we have investigated the antioxidative and hepatorenal protective potential of Spirulina platensis (SP) against beryllium (Be) induced alterations in hepatorenal biochemical parameters, oxidative stressand histopathological alterations in rats. Different doses of SP (50, 100, 200 and 400 mg/kg, p.o.) were administered (once aday daily for 7 days) against Be(NO3)2 (1 mg/kg, i.p. once a day daily, for 28 days) induced toxic menifestations in female Wistar rats. Be decreased GSH, SOD, CAT, G-6-Pase, ALP and ATPase activities and increased TBARS and ACP activityin liver and kidney. Be enhanced ALT, AST, bilirubin, uric acid, creatinine, total cholesterol and decreased haemoglobin,total protein, sugar in blood. Be deposited in vital organs of rats and altered the histoarchitecture of liver and kidney. Different doses of SP showed dose dependent recovery. SP @400 mg/kg showed significant recovery against Be inducedoxidative stress, maintained hepatorenal function towards normal and reduced beryllium body burden. Results of the study.well supported by histopathological observations, conclude that SP possesses hepatorenal protective potential againstBe induced toxicity in rats.

Keyword(s)

Berylliosis; Beryllium body burden; Chronic Beryllium Disease (CBD); Kidney; Liver; Oxidative stress

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