Evaluation of pharmacological and catalytic activity of CuO and Zn doped CuO nanoparticles

Abstract

CuO and Zn doped CuO nanoparticles (Zn-CuO NPs) with varying concentration i.e., ZnxCu_1−xO (where x = 0, 0.5, 1, and 1.5%) have been prepared via microwave assisted method. The spheroid structure of CuO NPs and the nanorod structure of ZnCuO NPs have been determined using High Resolution Scanning Electron Microscopy (HR-SEM) analysis. Elemental analysis has been carried out using Energy Dispersive X-ray Analysis (EDAX). The particle size and surface area of CuO and Zn-CuO NPs have been confirmed by Brunauer–Emmett–Teller (BET) method. The antibacterial studies have been revealed that Zn_(1.5%)-CuO NPs exhibited maximum zone of inhibition (19-29 mm) against the tested four bacterial strains. Zn-CuO NPs have been displayed robust action of antibacterial activity with minimum inhibitory concentration (MIC) of 0.09 µM against Campylobacter coli (C. Coli). DPPH and H2O2 radical scavenging assay investigation have been revealed that the significant scavenging activity has showed by Zn_(1.5%)-CuO. The in vitro cytotoxicity evaluation of synthesized material against human breast (MCF7) and human lung (A549) cancer cell lines have been demonstrated that Zn_(1.5%)-CuO NPs exhibited better cytotoxic activity against MCF7 cell lines (97.5% cell death) than A549 cell lines (90% cell death).