Novel pyrazole-pyridine containing 4-thiazolidinone hybrids: Design, synthesis and antimicrobial activity

Abstract

The emergence of antimicrobial resistance (AMR) to currently available antimicrobial agents is a major source of concern for scientists. Antibiotic treatment against numerous bacteria and fungus is no longer effective due to antimicrobial resistance, as bacteria and fungi have developed to fight antibiotics and proven them ineffective or less efficient. Novel antimicrobial drugs that are effective against resistant strains are desperately needed. In continuation to this, we have designed and synthesized 4-thiazolidinone clubbed pyridine-pyrazole analogues (5a-5o) for the evaluation of antimicrobial activity. The structures of the newly prepared compounds were analyzed and confirmed by using IR, ¹H NMR, ¹³C NMR and mass spectroscopy. Synthesized compounds have tested against various bacterial and fungal strains. Among the tested compounds, compounds 5b, 5g and 5m (MIC value of 62.5 μg/mL) have exhibited potency against E. coli gram-negative strain while compounds 5a, 5c, 5g, 5i and 5l (MIC = 250 μg/mL) were active against C. albicans fungal strain.