A new Ln(III) coordination polymer constructed from a hexadentate triazine ligand: Treatment activity and nursing value for ovarian cancer

Abstract

In this current paper, a 3D lanthanide (Ln) coordination polymer (CP), compound 1 with a chemical formula of [(NH₂(Me)₂)]₆·[Gd₃(TATAT)₂(μ₂-O)_1.5]·3EtOH·7.5H₂O is synthesized with the reaction between GdCl₃·6H₂O and 5,5′,5′′-(1,3,5-triazine-2,4,6-triyltriimino)tris(azanediyl) triisophthalate (H₆TATAT). Its treatment activity and nursing value against ovarian cancer is tested and the associated mechanism is analyzed simultaneously. At first, the CCK-8 detection is implemented to determine the suppression activity of compound 1 against the cell viability of ovarian cancer after treated via our compound. Furthermore, in order to detect the relative expression for the estrogen receptor on cells of ovarian cancer, real time RT-PCR is carried out.