Synthesis of novel indole substituted heterocyclics

Abstract

Herein is reported the synthesis of a series (21 number) of novel hybrid molecules composed of an indole-3-carbaldehyde attached to triazole/ isoxazole/ isoxazoline moieties having various aromatic/benzylic/aliphatic substitutions via 1,3-dipolar cycloaddition between azide/ nitrile oxide (dipole) and indole substituted alkyne/ alkene (dipolarophile) based on the importance of indole, 1,2,3-triazole, isoxazole and isoxazoline containing pharmacophores.