Synthesis, spectral characterization and anti-diabetic activity evaluation of phosphoramidate derivatives

Abstract

In the present work, a series of new phosphoramidate derivatives have been conveniently synthesized by using 4-chlorobenzene-sulfonyl chloride as preliminary material via substituted sulfonamides as intermediates with high yields in a short period by conventional and microwave irradiation techniques. All the synthesized compound have been characterized by spectral and elemental analyses. An in silico molecular docking study has been performed to find potent anti-diabetic drugs. In vitro anti-diabetic activity of the title compounds have also been screened by standard α-amylase inhibition assay. Some of the tested compounds have been proven to possess promising activity when compared with reference drug.