Syntheses, spectral characterization and antidiabetic activities of oxidovanadium(V) complexes with bi-and tridentate ligands

Abstract

Four new oxidovanadium(V) complexes [VO(L¹)(Mol)] (1), [VO(L²)(Mol)] (2), [VO(L³)(Mol)] (3) and [VO(L⁴)(Mol)] (4) (where L¹-L⁴ = aroylhydrazones and Mol = maltol) have been synthesized with different ligands. The complexes have been characterized using microanalysis, spectral fab mass, UV-visible, electrochemical (cyclic voltammetry and differential pulse voltammetry), density functional theory calculations have been performed to predict the optimized geometry, global reactivity parameters and electron density. In these complexes, the d-d absorption band is not observed as being d⁰ vanadium centres in these complexes. The electrochemical behaviour of these complexes are explored by cyclic voltammetry and differential pulse voltammetry (DPV). All complexes exhibit one electron transfer i.e., reduction of vanadium(V) to vanadium(IV). These complexes are screened for in vitro α-glucosidase and α-amylase inhibition study. Complex 3 has an interesting insulin-like activity.