Tin (IV) chloride catalysed synthesis of di(indolyl)methanes during electrophilic substitution of indoles and 2-methyl indoles
Abstract
An efficient methodology has been developed for the synthesis of di(indolyl)methanes in moderate to good yields during the study of the reactions of indole and 2-methyl indole using a series of aliphatic ketones in the presence of stannic chloride. It appears worth mentioning that with 2-methyl indole and acetone and ethyl methyl ketone the highly “elusive” indolylcarbinols, the postulated intermediates in the synthesis of di(indolyl)methanes, have been isolated.
Keyword(s)
Tin (IV) catalyst, ketones, indole, 2-methyl indole
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