Synthesis of hybrid peptides from unnatural aminoacids

Abstract

Hexa peptide 10 has been prepared by the condensation of tetrapeptide acid and dipeptide amine by using standard coupling reagents EDCI, HOBT and DIPEA. In the same method, terta peptide 8 has also been prepared from the acid of dipeptide 6 and amine salt of dipeptide 7 in dichloromethane. Dipeptide 5 has been prepared from the unnatural amino acid which is prepared from d-Glucose and Xyloses. NMR spectral data of peptides indicates presence of secondary structure in peptides.