Synthesis, characterization, antimicrobial and antitubercular activity of some new pyrimidine derivatives

Abstract

Pyrimidine heterocycles are proven to be biologically active heterocycles, found in many biological systems, displaying a broad spectrum of biological activities including anticancer, anxiolytic, antioxidant, antiviral, antifungal, anticonvulsant, antidepressant and antibacterial activities. New substituted 2-oxopyrimidines have been synthesized from the chalcones linked via indane-1,3-dione moity by the methods discussed in experimental section. We have synthesized some new 2-[6-(substituted phenyl)-2-oxo-1,2,5,6-tetrahydropyrimidin-4-yl]-indane-1,3-dione by reacting chalcones (step-1 compounds have been reported by us) with urea.