Design, synthesis and characterization of novel substituted pyrazol-azetidin-2-one derivatives for their antimicrobial activity

Abstract

A novel method is elucidated herein, describing the synthesis of novel 3-chloro-4-(2-substituted phenyl)-1-( 4'-((1-(5-( 4-substituted phenyl)-3-phenyl-4, 5-dihydro-1H-pyrazol-1-yl) ethylidene) amino)-[1,1'-biphenyl]-4-yl) azetidin-2-one, consisting of a pyrazol motif (prepared from chalcone) and a lactam ring ( synthesized from Schiff base of aromatic aldehyde) as a potential antimicrobial agent. The structural elucidation of the synthesized compounds have been confirmed from the elemental analysis, UV-Vis absorption spectroscopy, IR, ¹H NMR and mass spectral studies. The novel compounds have been subjected to in vitro antimicrobial screening against certain gram positive (S. aureus, B. subtilis) and gram negative (P. aeruginosa, E. coli) bacterial species. Compounds Vb, Vd and Ve are the most potent amongst all the synthesized compounds against the tested microbes.