Preparation and analysis of sodium carboxymethyl cellulose and its effect on xerophthalmia

Abstract

carboxymethyl cellulose (CMC) has been effectively synthesized with high yield and purity. With the prolongation of time after model establishment, the values of Schirmer Ⅰ test (S Ⅰ t) and breakup time of tear film gradually decreased. The α-MSH and CMC alone could ameliorate corneal tissue damage and corneal morphological abnormalities in the dry eye to some extent. However, compared with monotherapy, the treatment of α-MSH combined with CMC has a more significant positive effect on the improvement of tear secretion and the stability of tear film in dry eye model in the early stage after modeling. There are significant differences between the model control group and the normal control group at each time point after model establishment (all P<0.01) at 7^th, 14^th, 21^th and 28^th days after treatment. After 7, 14 and 21 days treatment, the S Ⅰ t values in the α-MSH+CMC treatment group were 4.80±0.79, 4.10±0.52 and 4.30±0.86 mm, respectively.