Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents

 

Satyanarayana, Mavurapu ; Shukla, Poonam ; Pratap, Ram ; Tripathi, Brajendra K; Srivastava, Arvind K; Tiwari, Priti

Abstract

A series of chalcone and flavone derivatives (6a-d, 9a-f) based on 2,4-thiazolidinedione have been synthesized and evaluated for in vivo antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models and also for antidyslipidemic activity in the triton model. Compounds 9d, 9e, and 9f exhibited potent blood glucose-lowering activity in both SLM and STZ models. Compounds 6c, 6d, and 9c, 9e, and 9f showed moderate lipid-lowering activity. The selected most potent compounds 6d and 9e were also studied in db/db mice for both antihyperglycemic and antidyslipidemic activity.


Keyword(s)

Chalcones, flavones, thiazolidinedione, antihyperglycemic activity, antidyslipidemic activity, sucrose loaded model, streptozotocin model, db/db mice, glitazones

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