Correlation of serum fructosamine, erythrocyte Na+-K+ ATPase and glutathione peroxidase with HbA1c levels

Abstract

Glycated hemoglobin is the frequently used test in the diagnosis of diabetes mellitus. However, because this test is affected by various factors and may not be accurate for patients of certain health conditions, the present study aims to explore the association between potential and cost-effective markers like serum Fructosamine, Erythrocyte Na⁺-K⁺ ATPase, and Glutathione peroxidase with altering levels of established marker HbA1c (Glycated haemoglobin). The study showed that serum Fructosamine has a statistically significant (P = <0.0001) association with increasing levels of HbA1c as well as blood glucose. There was a 100% sensitivity and specificity for serum fructosamine test against HbA1c in ROC analysis, however, the erythrocyte glutathione peroxidase and erythrocyte membrane Na+-K+ ATPase activity was not affected by increasing HbA1c levels.